1. What is Ziatozone and how does it work?

Ziatozone is a topical massage cream containing ozonated oil, menthol, eucalyptus, camphor, amino acids (arginine, leucine, valine, glutamic acid), and Harpagophytum (Devil’s Claw) root extract. It relieves pain through multiple mechanisms:

• Anti inflammatory action: Ozonated oil and Devil’s Claw inhibit inflammatory enzymes (like COX), reducing local inflammation. Ozone also modulates oxidative stress and promotes antioxidant defense.
• Analgesic effect: Menthol and camphor activate TRP channels to deliver a cooling/warming counter irritant effect that masks pain.
• Circulation & muscle recovery: Arginine supports nitric oxide production, improving microcirculation; branched-chain amino acids help reduce delayed-onset muscle soreness.

2. What conditions does Ziatozone target?

• Osteoarthritis and joint pain (knee, hip, shoulder)

• Muscle strains, ligament sprains, and sports injuries
• Post-exercise muscle soreness (DOMS)
• Tension and inflammatory soft-tissue pain

3. How should I apply it?

Apply a thin layer of Ziatozone on clean, dry skin over the affected area. Massage in circular motions until fully absorbed. Use 2–3 times daily or after intense activity for optimal results.

4. When will I start feeling relief?

Many users notice a cooling/warming soothing sensation immediately. Significant pain reduction and inflammation relief often appear within 3–5 days of regular use. Long term benefits may emerge within 1–2 weeks.

5. Is Ziatozone safe? Any side effects?

It’s generally safe when used topically. Mild reactions like skin redness or irritation may occur from menthol or camphor. Ozone oil and Devil’s Claw have been well-tolerated in clinical settings.
• Allergies: Rare skin reactions possible.
• Devil’s Claw oral use: May cause stomach upset or interact with medications, but topical use minimizes this risk.

6. Can it be used on broken or irritated skin?

No, avoid applying Ziatozone on open wounds, cuts, or mucous membranes (eyes, mouth). Use only on healthy, intact skin.

7. Is Ziatozone suitable for elderly patients or pregnant women?

Elderly individuals can use it safely. However, pregnant or breastfeeding women, and children under 5, should consult a physician before use due to limited data.

8. Can I use it with other topical creams?

It’s best not to mix Ziatozone with other NSAID gels or menthol-containing products simultaneously, as this may lead to skin irritation or compounded effects.

If you have further questions or unusual symptoms, please consult a healthcare provider.
9. How long does a tube last?

Depending on usage frequency, a standard tube (typically 50–100 mL) lasts 2–4 weeks. Exact duration varies by application thickness and treated area.

10. Does Ziatozone interact with medicines?

Topical use causes minimal systemic absorption, so drug interactions are unlikely. However, patients using anticoagulants, diabetes medication, or anti hypertensives should consult their physician, especially if using Harpagophytum extract.

11. What age group is Ziatozone for?

Recommended for adults and seniors. Use in children under 5 is not advised. Older adults with comorbid conditions should consult a healthcare provider.

12. Is it clinically supported?

Yes. A randomized, placebo-controlled trial demonstrated that topical ozonated oil significantly relieved pain in severe knee osteoarthritis patients (PubMed). Devil’s Claw extract has shown similar results to NSAIDs in arthritis pain relief (Versus Arthritis).

13. How often can I use Ziatozone?

Up to 2–3 times per day. Do not exceed 4 applications in 24 hours or use it under occlusive dressings without medical advice.

14. Can I use it for muscle soreness after workouts?

Absolutely. The ozonated oil supports circulation and recovery, while amino acids help reduce post-exercise muscle soreness (DOMS).

15. Where should I store Ziatozone?

Store in a cool (<30 °C), dry place away from direct sunlight. Keep the cap tightly sealed to maintain stability.